12-Months Clinical Comparison between Osteoinductal® and Emdogain® for the Treatment of Intrabony Defects

Results of basic research, animal experiments as clinical studies have suggested the influence of an oily Calcium Hydroxide suspension on bone regeneration in closed defects. Its osteostimulative effect, which can be characterized as biologic, seems to rely on factors as the deposit action of the Calcium Hydroxide (sustaining the bone metabolism in a constant, long-lasting mild alkalic environment), the stimulation of the angiogenetic bone growth and, possibly, the concentration of the growth factors next to the defect wall. OCHS have been also proven to reduce the inflammation in the operated site, thus enhancing the wound healing. Histological and radiological analysis, both in animals and humans, suggest a certain amount of regeneration in periodontal defects. So far, there is only one clinical controlled study to compare at six months the effect of the oily Calcium Hydroxide suspension with EMD in periodontal intrabony defects.